Health
Maltipoo health problems: 9 conditions and their signs
Igor, founder of ZoozyJars and maltipoo owner · Updated October 26, 2026 · 6 min read
The most common maltipoo health problems are the same ones its parents have: dental disease, luxating patella, portosystemic shunt from the Maltese side, progressive retinal atrophy from the poodle side and tracheal collapse. Being a cross doesn't protect against the parents' diseases, so the health tests of the mother and father tell you the most about a puppy's future.
Below are 9 conditions worth knowing, with the signs and what to do.
- Teeth and kneecaps are the two most common weak spots in small dogs.
- From the Maltese: portosystemic shunt and "white dog" shaker syndrome. From the poodle: PRA.
- A PRA-prcd DNA test in both parents is the minimum when you buy.
- A harness, a lean body and pet steps take load off the windpipe and knees.
- Get insurance before the first symptoms.
Go to the vet straight away if:
- a puppy is floppy, trembling, wobbly or hasn't eaten for over ten hours,
- your dog has a seizure (film it and note how long it lasts),
- a puppy grows poorly, walks in circles or seems dull after meals,
- your dog suddenly limps, has a "goose-honk" cough or bumps into furniture at dusk.
Are crossbreeds healthier than their parents
A popular belief says crossbreeds are healthier ("hybrid vigour"). The Royal Veterinary College analysed records of 9,402 dogs: cockapoos, labradoodles and cavapoos versus their parent breeds, including toy, miniature and standard poodles. Across 57 common conditions, 86.6% of comparisons showed no difference. The crossbreed was at higher risk in 7.0% of comparisons and at lower risk in 6.4%.
Maltipoos weren't studied separately, but the conclusion is the same: the specific parents decide. When I bought Zuzi, what mattered most to me was who her parents were, how they looked and their overall quality. Her mother is a friend's own dog, not from a mass breeder.
9 maltipoo health problems in one table
| Condition | From | Signs | What to do |
|---|---|---|---|
| Dental and gum disease | both | bad breath, tartar, red gums | daily tooth brushing, check at every vet visit |
| Luxating patella | both | "skipping" on three legs, stiff gait after getting up | orthopaedic vet, lean body, fewer jumps |
| Portosystemic shunt (PSS) | Maltese | puppy grows poorly, circles, dull after meals | vet urgently, usually treated with surgery |
| "White dog" shaker syndrome | Maltese | rhythmic whole-body trembling, worse with excitement, eases in sleep | vet, usually steroid treatment |
| Progressive retinal atrophy (PRA) | poodle | worse vision at dusk, bumping into furniture | DNA test of the parents, eye exam |
| Tracheal collapse | both | dry "goose-honk" cough, worse when pulling on a collar | harness instead of a collar, vet |
| Puppy hypoglycaemia | both | weakness, trembling, wobbly walking | urgent vet visit |
| Epilepsy | both | recurring seizures | film the seizure, note the time, call the vet |
| Tear stains under the eyes | both | red-brown streaks, yellow or green discharge if infected | wipe daily, see the vet if there's discharge |
Teeth and kneecaps: the two most common weak spots
In dogs under 6.5 kg, periodontal disease is diagnosed up to 5 times more often than in dogs over 25 kg (Banfield, over 3 million records). It affects 28.9% of toy poodles. Crowded teeth in a small jaw trap food debris, and tartar builds up fast. How to brush and when a dental cleaning is needed is in tartar on dog teeth.
With a luxating patella, the kneecap "pops" out of its groove in the thigh bone. The typical picture: your dog is running, suddenly hops a few steps on three legs, then carries on as normal. Even if the sign passes, show your dog to an orthopaedic vet. Grades and treatment are covered in luxating patella in dogs.
Conditions from the Maltese and from the poodle
Portosystemic shunt (PSS) is a congenital blood vessel that bypasses the liver, so the blood isn't filtered. It's usually treated with surgery, and the shunt is successfully closed in 84–95% of cases.
"White dog" shaker syndrome is whole-body trembling of unknown cause, usually at 1–2 years of age and more often in small white dogs. It usually responds to steroid treatment within 1–2 weeks, and the outlook is good (VCA Hospitals).
PRA is an inherited disease that gradually leads to blindness. The most common form, PRA-prcd, is detected by a simple DNA test of the parents. Ask the breeder for the result in writing.
Windpipe, blood sugar, epilepsy and tear stains
Tracheal collapse means the cartilage rings of the windpipe soften. It's typical of toy breeds and more common in middle-aged and older dogs.
Hypoglycaemia is a risk for very small puppies with little in reserve. Their blood sugar can drop between meals, which is why a puppy under 4 months eats 4 times a day.
Epilepsy means recurring seizures with a genetic or unknown cause. A video of the seizure and its length help your vet a lot.
Tear stains come from tear pigment (porphyrins) and show most on a light coat. Daily care is covered in tear stains in dogs.
What you can do yourself and when to insure
- A lean body. Every extra kilogram on a 4 kg dog is 25% more body weight. Zuzi is 6 and weighs 4–4.3 kg, so for us this maths is very real.
- A harness instead of a collar, for less pressure on the windpipe.
- Tooth brushing from the first weeks at home.
- Steps or a ramp instead of jumps off the sofa and bed.
- A yearly check-up, every six months for seniors.
Treating a shunt or kneecap surgery can cost from several hundred to over a thousand euros. Look at pet insurance before the first symptoms appear, because congenital conditions reported earlier are usually not covered. This is not financial advice: read the terms of the specific insurer.
There's more on the breed, from size to grooming, in our maltipoo guide.
Frequently asked questions
There's no evidence for that. In a 2024 RVC study (9,402 dogs, poodle crosses and their parent breeds), 86.6% of comparisons showed no difference in risk. Maltipoos weren't studied separately.
Bryson et al., PLOS ONE 2024;19(8):e0306350 (RVC); Banfield, over 3 million records (Vet Times 2021); Poodle Club of America 2024; VCA Hospitals: Shaker syndrome; AKC: Hypoglycemia in dogs; Embrace Pet Insurance: Maltese; Hill's: common health problems in small dogs; MetLife Pet Insurance; PetMD: Epiphora. This article is for education only and does not replace advice from a veterinarian.
About the author
Igor, founder of ZoozyJars and maltipoo owner
I run ZoozyJars and live with a maltipoo myself. I write from my own experience and lean on the sources listed under each article.
Read our storyRead next
Personal food plan
How much, and what, does your dog need?
Answer a few questions about breed, weight, age and activity. We'll work out the daily portion in calories and a set of ZoozyJars flavours.
Get personalised planA daily ritual. A personal plan. Yours to pause anytime.